The Waisman Brain Imaging Lab recruits human subject research participants on a regular basis; however, not all projects are actively recruiting participants at this time. Most of our projects involve at least one laboratory session in Madison, WI. Sometimes follow-up sessions are required that may occur several months later.
For more information, please see our Study Recruitment page.
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• ongoing research programs
• retaining highly skilled personnel
• maintaining and updating equipment and infrastructure among others
To make an online gift, please see the UW Foundation site
Summer 2013: fMRI Analysis Expert
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"Early neglect is associated with alterations in white matter integrity and cognitive functioning" (Hanson et al., September 2013, Child Development).
The researchers found that organization of white matter in the prefrontal cortex was related to early neglect and also to the issues with planning and learning exhibited by these children. In children who had suffered early neglect, white matter in the prefrontal cortex was connected very diffusely. Prefrontal white matter in children who had not suffered such early maltreatment was organized in a very directed fashion, connecting to parts of the brain in specific ways. Diffuse brain connectivity may be related to less effective processing of information needed to plan or learn patterns.
“Prenatal Stress Induces Increased Striatal Dopamine Transporter Binding in Adult Nonhuman Primates” (Converse et al., June 2013, Biological Psychiatry).
The dopamine transporter (DAT) regulates dopamine in synapses and is linked to brain circuitry for movement, emotion, attention, and possibly ADHD. We used positron emission tomography to scan adult rhesus monkeys who had been prenatally exposed to mild daily stress and found increased DAT in striatum compared to controls. Animals with higher DAT showed greater response and slower habituation to tactile stimulation. Thus mild prenatal stress may affect both DAT and behavior in adulthood.
"Serotonin Transporter Genotype Affects Serotonin 5-HT1A Binding in Primates. " (Christian et al., Feb 2013, Journal of Neuroscience).
This research was performed to measure the 5-HT1A neurochemical endophenotype of the 5-HTTLPR polymorphism. Rhesus monkeys possess a 5-HTTLPR length polymorphism similar to humans and serve as an excellent model for studying the effects of this orthologous genetic variation on neurochemical functions related to the 5-HT system. Significantly lower 5-HT1A binding was found in s-carrier subjects throughout both cortical brain regions and the raphe nuclei. These results demonstrate that the underlying 5-HT neurochemical system is influenced by this functional polymorphism.
February 10: Alex Converse recently published a paper, titled "Tai chi training reduces self-report of inattention in healthy young adults", which as been listed as one of the Top 10 most viewed research articles from the Frontiers in Neuroscience journals